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Department of Ubiquitous Health Informatics,
1.Overview
Our mission is to promote research and development of a novel integration system where pieces of patients’ healthcare information are virtually combined together that are stored separately in diverse medical/healthcare facilities. Recently developed mobile information communication technologies in conjunction with cloud computing provide sturdy environment to build a “virtual ubiquitous health information space”. We particularly focus on better clinical outcomes, as well as efficacy, safety, and security matters achieved by those innovative systems in the various medical/healthcare fields.
2.Research Projects
To date we have been working on specific topics shown below since this lab was established in 2009. Our products have reached a stage of clinical validation, respectively. Furthermore, we are promoting collaborative research with several laboratories both inside and outside the campus, seeking for frontier fields of interdisciplinary research and practical medicine/healthcare fields. Through development of those specific products, we further aim to establish a systematic methodology for creating solutions for virtual ubiquitous health information space.
1.A 12-lead ECG system based on cloud computing for emergency care
Treatment of cardiovascular diseases inside medical facilities have improved dramatically in recent years. On the other hand, the outcomes of acute cardiovascular disease is not yet sufficient depending upon the local medical environment. In order to fill up those “gaps” between inside and outside the medical facilities, we working on creating a novel ECG system as a clinically valid approach to this problem. We have developed a cloud computing system with wirelessly transmission ECG units, potentially clinical usefulness due to the cloud-based server built. Deliverables of this study demonstrate that the application will be tested in several clinical fields FY2011.
2. Dialbetics: A novel smartphone-based self-management support system for type 2 diabetic patients
It is fundamentally important for diabetic patients to maintain appropriate balance of diet and exercise, although the clear solution for it has not yet been established. We have developed a novel smartphone-based self-management support system for type 2 diabetic patients. This new system has an automatic function of stratifying daily patient's biometric information such as blood glucose, blood pressure, and food intake retrieved by the home sensor and router according to medical risk evaluation. Stratification engine feedback the risk level and raw data to the patients, as well as to the administrator only if the risk level indicates extremely high so that he/she can urge the patient to see or consult his health professionals as soon as possible. It has long been pointed out that introduction of telemedicine can problematically increase the burden of healthcare workers, even if its efficacy may be ascertained, suggesting the difficulties to maintain and promote the system. We are also struggling to develop a new system to overcome this kind of apprehension by developing a new algorithm to reduce the burden of health care workers. At present we performed series of pilot studies for about 10 people in accordance with the reviewed protocol of the ethics committee. We are to conduct 100-scale clinical trial to further confirm validation, efficacy and safety aspects of Dialbetics in FY2011. Besides we promote the evolutional algorithm in collaboration with a specific research laboratory in Faculty of Engineering.
3. Integrated System on Smartphone for Medicine Taking Support to maintain adherence to medication
In clinical settings, adherence to medication is a potentially important issue, previously managed by maintaining its objective methodology has not been reliably established. We have sought a solution by mobile ICT, which deals with prescribing information from the hospital as well as dispensing information from a pharmacy, and centralizes the medicine-taking information obtained through wireless sensing unit equipped in the pill cabinet and a newly developed integrated application. This enables us to share information about patients’ adherence to medication among healthcare providers and patients.
4. Advanced smartphone-based guidance system for outpatients
In order to improve convenience and amenity of university hospital outpatient services, we have developed a new guidance system on cell phones. This system will provide advanced function for reception from outside, reducing waiting time, fast-forward of prescription data to pharmacies, and so on. It will be tested in the outpatient department of the University of Tokyo Hospital in FY2011.
5. Various assistance applications on smartphone for medical/comedical personnel in hospitals
We have launched several development projects of mobile ICT systems to assist medical staff and medical technicians in the hospital.
3.Future directions
We further promote development and validation of these five themes. In particular, themes #1 to #3 are expected to exert clinical efficacy, which will be tested in practical world. In addition to university hospital outpatient/ward, we will examine various models of health care, such as community health care, and home care as joint research. To pursue scientific value of both clinical medicine and medical informatics for the establishment of spatial generalization we will move onto establishing virtual cyberspace for medical/health informatics.
4.Papers, published in FY 2010
・Kiyosue A, Hirata Y, Ando J, Fujita H, Morita T, Takahashi M, et al. Relationship between renal dysfunction and severity of coronary artery disease in Japanese patients. Circ J 2010;74:786-791.
・Kiyosue A, Hirata Y, Ando J, Fujita H, Morita T, Takahashi M, et al. Plasma cystatin C concentration reflects the severity of coronary artery disease in patients without chronic kidney disease. Circ J 2010;74:2441-2447.
・Iwata H, Sata M, Ando J, Fujita H, Morita T, Sawaki D, et al. Impact of primitive cells in intracoronary thrombi on lesion prognosis: temporal analysis of cellular constituents of thrombotic material obtained from patients with acute coronary syndrome. Heart 2010;96:748-755.
・Kawashima D, Ohno T, Kinoshita O, Motomura N, Kiyosue A, Fujita H, et al. Prevalence of vitreous hemorrhage following coronary revascularization in patients with diabetic retinopathy. Circ J 2011;75:329-335.
・Fujita H, Nagai R. Glycemic Control Is Another Target of PCI in Diabetic Patients. Circ J 2011;75:773-774.
・Waki K, Sugawara Y, Tamura S, Yamashiki N, Fujita H, Kadowaki T, Kokudo N
Simultaneous Pancreas-Kidney Transplantation in the United States: An Analysis of the UNOS Registry. Clin Transpl. 2010:35-44.
・Ohe H, Ying Li, Nafady-Hego H, Waki K, Sakaguchi S, Wood K, Calne R, Uemoto S, Koshiba T Minimal But Essential Doses of Immunosuppression: A More Realistic Approach to Improve Long-Term Outcomes for Pediatric Living-Donor Liver Transplantation. Transplantation. 2011 April; 91(7):809-810.
・Waki K, Hayashi A, Ikeda S, Ikeda S, Nagatsuka K, Honma Y, Kadowaki T, Yoshinoya S Measuring platelet aggregation in dialysis patients with a whole blood aggregometer by the screen filtration pressure method. Ther Apher Dial. 2011 Apr;15(2):203-6
・Waki K, Terasaki PI, Kadowaki T
Long Term Pancreas Allograft Survival in Simultaneous Pancreas Kidney Transplantation by Era. Diabetes Care. 2010 Aug;33(8):1789-91.
・Aramaki E, Miura Y, Tonoike M, Ohkuma T, Mashuichi H, Waki K, Ohe K
Extraction of Adverse Drug Effects from Clinical Records
Stud Health Technol Inform. 2010;160(Pt 1):739-43.
Department of Ubiquitous Health Informatics,
School of Medicine, The University of Tokyo
1.Overview
Our mission is to promote research and development of a novel integration system where pieces of patients’ healthcare information are virtually combined together that are stored separately in diverse medical/healthcare facilities. Recently developed mobile information communication technologies in conjunction with cloud computing provide sturdy environment to build a “virtual ubiquitous health information space”. We particularly focus on better clinical outcomes, as well as efficacy, safety, and security matters achieved by those innovative systems in the various medical/healthcare fields.
2.Research Projects
To date we have been working on specific topics shown below since this lab was established in 2009. Our products have reached a stage of clinical validation, respectively. Furthermore, we are promoting collaborative research with several laboratories both inside and outside the campus, seeking for frontier fields of interdisciplinary research and practical medicine/healthcare fields. Through development of those specific products, we further aim to establish a systematic methodology for creating solutions for virtual ubiquitous health information space.
1.A 12-lead ECG system based on cloud computing for emergency care
Treatment of cardiovascular diseases inside medical facilities have improved dramatically in recent years. On the other hand, the outcomes of acute cardiovascular disease is not yet sufficient depending upon the local medical environment. In order to fill up those “gaps” between inside and outside the medical facilities, we working on creating a novel ECG system as a clinically valid approach to this problem. We have developed a cloud computing system with wirelessly transmission ECG units, potentially clinical usefulness due to the cloud-based server built. Deliverables of this study demonstrate that the application will be tested in several clinical fields FY2011.
2. Dialbetics: A novel smartphone-based self-management support system for type 2 diabetic patients
It is fundamentally important for diabetic patients to maintain appropriate balance of diet and exercise, although the clear solution for it has not yet been established. We have developed a novel smartphone-based self-management support system for type 2 diabetic patients. This new system has an automatic function of stratifying daily patient's biometric information such as blood glucose, blood pressure, and food intake retrieved by the home sensor and router according to medical risk evaluation. Stratification engine feedback the risk level and raw data to the patients, as well as to the administrator only if the risk level indicates extremely high so that he/she can urge the patient to see or consult his health professionals as soon as possible. It has long been pointed out that introduction of telemedicine can problematically increase the burden of healthcare workers, even if its efficacy may be ascertained, suggesting the difficulties to maintain and promote the system. We are also struggling to develop a new system to overcome this kind of apprehension by developing a new algorithm to reduce the burden of health care workers. At present we performed series of pilot studies for about 10 people in accordance with the reviewed protocol of the ethics committee. We are to conduct 100-scale clinical trial to further confirm validation, efficacy and safety aspects of Dialbetics in FY2011. Besides we promote the evolutional algorithm in collaboration with a specific research laboratory in Faculty of Engineering.
3. Integrated System on Smartphone for Medicine Taking Support to maintain adherence to medication
In clinical settings, adherence to medication is a potentially important issue, previously managed by maintaining its objective methodology has not been reliably established. We have sought a solution by mobile ICT, which deals with prescribing information from the hospital as well as dispensing information from a pharmacy, and centralizes the medicine-taking information obtained through wireless sensing unit equipped in the pill cabinet and a newly developed integrated application. This enables us to share information about patients’ adherence to medication among healthcare providers and patients.
4. Advanced smartphone-based guidance system for outpatients
In order to improve convenience and amenity of university hospital outpatient services, we have developed a new guidance system on cell phones. This system will provide advanced function for reception from outside, reducing waiting time, fast-forward of prescription data to pharmacies, and so on. It will be tested in the outpatient department of the University of Tokyo Hospital in FY2011.
5. Various assistance applications on smartphone for medical/comedical personnel in hospitals
We have launched several development projects of mobile ICT systems to assist medical staff and medical technicians in the hospital.
3.Future directions
We further promote development and validation of these five themes. In particular, themes #1 to #3 are expected to exert clinical efficacy, which will be tested in practical world. In addition to university hospital outpatient/ward, we will examine various models of health care, such as community health care, and home care as joint research. To pursue scientific value of both clinical medicine and medical informatics for the establishment of spatial generalization we will move onto establishing virtual cyberspace for medical/health informatics.
4.Papers, published in FY 2010
・Kiyosue A, Hirata Y, Ando J, Fujita H, Morita T, Takahashi M, et al. Relationship between renal dysfunction and severity of coronary artery disease in Japanese patients. Circ J 2010;74:786-791.
・Kiyosue A, Hirata Y, Ando J, Fujita H, Morita T, Takahashi M, et al. Plasma cystatin C concentration reflects the severity of coronary artery disease in patients without chronic kidney disease. Circ J 2010;74:2441-2447.
・Iwata H, Sata M, Ando J, Fujita H, Morita T, Sawaki D, et al. Impact of primitive cells in intracoronary thrombi on lesion prognosis: temporal analysis of cellular constituents of thrombotic material obtained from patients with acute coronary syndrome. Heart 2010;96:748-755.
・Kawashima D, Ohno T, Kinoshita O, Motomura N, Kiyosue A, Fujita H, et al. Prevalence of vitreous hemorrhage following coronary revascularization in patients with diabetic retinopathy. Circ J 2011;75:329-335.
・Fujita H, Nagai R. Glycemic Control Is Another Target of PCI in Diabetic Patients. Circ J 2011;75:773-774.
・Waki K, Sugawara Y, Tamura S, Yamashiki N, Fujita H, Kadowaki T, Kokudo N
Simultaneous Pancreas-Kidney Transplantation in the United States: An Analysis of the UNOS Registry. Clin Transpl. 2010:35-44.
・Ohe H, Ying Li, Nafady-Hego H, Waki K, Sakaguchi S, Wood K, Calne R, Uemoto S, Koshiba T Minimal But Essential Doses of Immunosuppression: A More Realistic Approach to Improve Long-Term Outcomes for Pediatric Living-Donor Liver Transplantation. Transplantation. 2011 April; 91(7):809-810.
・Waki K, Hayashi A, Ikeda S, Ikeda S, Nagatsuka K, Honma Y, Kadowaki T, Yoshinoya S Measuring platelet aggregation in dialysis patients with a whole blood aggregometer by the screen filtration pressure method. Ther Apher Dial. 2011 Apr;15(2):203-6
・Waki K, Terasaki PI, Kadowaki T
Long Term Pancreas Allograft Survival in Simultaneous Pancreas Kidney Transplantation by Era. Diabetes Care. 2010 Aug;33(8):1789-91.
・Aramaki E, Miura Y, Tonoike M, Ohkuma T, Mashuichi H, Waki K, Ohe K
Extraction of Adverse Drug Effects from Clinical Records
Stud Health Technol Inform. 2010;160(Pt 1):739-43.